January’s Deals to Destinations highlights the breadth and momentum of angel investing across the ACA community. This month’s report features investments spanning healthcare, life sciences, climate and energy, AI, advanced instrumentation, and consumer innovation—demonstrating how angel capital continues to fuel solutions with real-world impact. From early-stage therapeutics and next-generation surgical tools to clean energy and data-driven platforms, these investments reflect both the diversity of angel group participation and the depth of opportunity across the ecosystem. The update also includes a recent positive exit, underscoring how patient, disciplined capital can translate into meaningful outcomes.

Investments:

1. Buck Surgical, Inc. is a St. Louis-based company that develops surgical care that improves outcomes, helps to modernize limb-preservation treatments in vascular and gastrointestinal surgery. It received a $130,000 investment from St. Louis Arch Angels in Q3, 2025.
2. GreenJay Therapeutics is a Conroe, Texas-based company that has developed a new formulation of a drug that does not contain a toxic excipient that is currently used. It received a $342,000 investment from Austin-based Central Texas Angel Network in Q4, 2025.
3. Milkify is a Houston, Texas-based company that creates freeze-dried breast milk powder that can be used as an affordable human milk fortifier. It received a $347,900 investment from Austin, Texas-based Central Texas Angel Network in Q4, 2025.
4. Ordaos Bio, Inc. is a New York City-based company that is working to create novel therapies that reduce patient suffering for overlooked patients using novel, generative AI-designed miniPRO proteins. It received a $250,000 investment from San Diego, California-based NuFund Venture Group in Q4, 2025.
5. Tundra Targeted Therapeutics is a Milwaukee, Wisconsin-based company that is a developer of antibodies designed to improve cancer treatment. It received a $400,000 investment from San Diego, California-based NuFund Venture Group in Q4, 2025.
6. Evecxia Therapeutics is a Research Triangle Park, North Carolina-based company dedicated to realizing the therapeutic potential of serotonin synthesis amplification to enable people with mental illness lead fuller, more meaningful lives. It received an $85,000 investment from Ft Worth, Texas-based Cowtown Angels.
7. Exum Instruments, Inc. is a Denver, Colorado-based company that enables scientists and engineers to spend less time acquiring data and more time learning from it, delivering chemistry at the point of need. It received a $690,000 investment from Minneapolis, Minnesota-based Gopher Angels in Q3, 2025.
8. NICKI.pass is a Philadelphia, Pennsylvania-based company that helps executives access news and information and helps companies save money on news subscriptions. It received a $120,000 investment from Phoenix, Arizona-based Arizona Tech Investors in Q3, 2025.
9. Tandem PV is a San Jose, California-based company that manufactures next-gen solar panels, resulting in a 30%-40% efficiency improvement over traditional silicon. It received a $160,000 investment from Phoenix, Arizona-based Arizona Tech Investors in Q3, 2025.
10. Shower Stream (Abstract Engineering, Inc.) is an Austin, Texas-based company that is helping the hospitality industry minimize shower water waste and identify potential maintenance issues in real time through its universally compatible shower head. It received a $115,000 investment from Dallas, Texas-based North Texas Angel Network in Q3, 2025.
11. Unified Track is a Knoxville, Tennessee-based company that is developing an AI-driven predictive analytics platform intended to help high school counselors keep students on track. It received a $345,000 investment from Southern California-based TCA Venture Group in Q3, 2025.
12. Amplifi Vascular is a Chesterfield, Missouri-based company that is poised to disrupt the access and bypass space by creating larger, faster, quality autologous veins. It received a $35,000 investment from Tucson, Arizona-based Desert Angels in Q4, 2025.
13. CAKE is an Arlington, Texas-based company that operates a two-sided marketplace that operates on an annual membership basis. Aspirational female clothing brands are seeking new client acquisition methods and love the zero-cost approach to CAKE. On the buyer side, members get discounts on brands that often never obtain discounts. It is a win-win. It received a $1,300,000 investment from Boston, Massachusetts-based Launchpad Venture Group in Q1, 2025.
14. Atraverse is a Chicago, Illinois-based company that is developing the next-generation toolset for transseptal crossing, which is a necessary procedural step for a myriad of cardiac interventions. It received a $1,540,000 investment from New York City-based New York Angels in Q2, 2025.

Exits:

1. Xeno Biosciences is a Boston, Massachusetts-based company that has been developing a drug to address obesity. It received a $298,000 investment from a New Orleans, Louisiana-based company from Gulf Soth Angels in 2021 and provided a positive exit in Q2, 2025.

How to Participate: 
We encourage all ACA member groups to take part by sharing their investment and exit data. If your group is interested in joining the rollout, please reach out to the ACA team for details on how to contribute.

Stay tuned for the first official edition of this new series, and thank you to the 16 angel groups already committed to helping ACA tell the powerful story of angel investing in action.